Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/20/2025

Guidelines for Trial of Labor After Cesarean

Candidate Selection for TOLAC

  • The American Academy of Family Physicians recommends that previous vaginal birth is the strongest predictor of successful vaginal birth after cesarean, with approximately 74% of women who attempt TOLAC having a successful vaginal birth 1
  • Women who have had a previous VBAC have an even greater chance of success compared to those who have not 1
  • TOLAC is appropriate for most women who have had one or two cesarean deliveries with low transverse uterine incisions 1

Anesthetic Considerations

  • The American Society of Anesthesiologists recommends that neuraxial techniques should be offered to patients attempting VBAC 3
  • Early placement of a neuraxial catheter is appropriate for women attempting VBAC, as it can be used later for labor analgesia or anesthesia if operative delivery becomes necessary 3
  • An intravenous infusion should be established before initiating neuraxial analgesia and maintained throughout the duration of the analgesic or anesthetic 3

Risk Factors for Uterine Rupture

  • Labor induction with oxytocin carries a 1.1% risk of uterine rupture (95% CI, 0.9% to 1.5%) 2
  • Labor induction with prostaglandin E2 carries a 2% risk of uterine rupture (95% CI, 1.1% to 3.5%) 2
  • Misoprostol is contraindicated due to a significantly higher risk of uterine rupture 2

Outcomes and Benefits

  • The American Academy of Family Physicians states that short-term maternal outcomes are as good or better with TOLAC/VBAC compared to repeat cesarean delivery 1
  • Perinatal mortality is slightly higher with TOLAC compared to repeat cesarean delivery 1
  • Repeat cesarean delivery increases long-term risk of abnormal placentation, hysterectomy, and surgical complications compared with VBAC 1

Special Considerations

  • Physicians should discuss reasons for previous cesarean delivery when counseling patients about TOLAC 1
  • Predictive scoring models have limited value in determining which women have a greater risk of cesarean delivery 1