Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/19/2025

Ventilation in Neonatal Resuscitation

  • The American Academy of Pediatrics recommends ventilation at a rate of 40 to 60 breaths per minute to maintain or rapidly achieve a heart rate above 100 beats per minute 1, 2
  • Ventilation is the most effective action during neonatal resuscitation, as bradycardia in newborns is generally the result of inadequate lung inflation or profound hypoxemia 2
  • A rate of 40 to 60 breaths per minute is recommended, which corresponds to ventilation every 1 to 1.5 seconds 1, 3
  • The primary goal of adequate ventilation is rapid improvement of heart rate, which should be continuously monitored 3

Ventilation Technique

  • The initial inflation pressure may be 20 cm H₂O, but ≥30 to 40 cm H₂O may be necessary in some newborns without spontaneous ventilation 1, 3
  • Inflation pressures should be monitored and individualized to achieve an increase in heart rate or chest movement with each breath 3

Coordination with Chest Compressions

  • If the heart rate remains <60 beats/minute despite 30 seconds of adequate ventilation with supplemental oxygen, chest compressions are indicated 2, 4
  • During chest compressions, a ratio of 3:1 (compressions:ventilations) is recommended, with 90 compressions and 30 breaths to achieve approximately 120 events per minute 2, 5
  • Each event lasts approximately 0.5 seconds, with exhalation occurring during the first compression after each ventilation 2, 4

Important Considerations

  • The quality of ventilation is more important than the quantity; it is essential to ensure that the chest rises with each ventilation 6

Surveillance and Adjustments

  • Improvement in heart rate is the primary indicator of effective ventilation 3
  • If the heart rate does not improve, it is necessary to check the movement of the chest wall 3
  • A heart rate below 60 beats/minute despite adequate ventilation for 30 seconds is an indication to start chest compressions 7