Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/23/2025

Management of Mucinous Ovarian Tumors

Surgical Management

  • The National Comprehensive Cancer Network (NCCN) guidelines recommend that appendectomy must be performed in all patients with mucinous ovarian tumors because of the significant risk of synchronous appendiceal pathology 1, 2
  • Appendectomy should be performed in all mucinous tumors and considered in all patients with epithelial malignancies suspicious for appendiceal metastases, as stated by the NCCN guidelines 2
  • Grade 3 tumors warrant appendectomy due to reports of the appendix being the only site of extra-ovarian spread 1, 3
  • Routine appendectomy in early ovarian cancer remains controversial and is performed in less than 4% of cases 1, 3
  • When gross tumor involvement of the appendix is visible, appendectomy is mandatory regardless of histologic type 4

Clinical Implications

  • Failing to perform appendectomy in mucinous tumors is the most significant error, as 8% will have appendiceal involvement 1

REFERENCES

1

surgery for ovarian cancer: rationale and guidelines. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2004

2

epithelial ovarian cancer. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2011

3

surgery for ovarian cancer: rationale and guidelines. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2004

4

surgery for ovarian cancer: rationale and guidelines. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2004