Sucralfate Treatment for Stomach and Duodenal Ulcers

Introduction to Sucralfate Therapy

• For H. pylori-associated ulcers, eradication therapy should be used in addition to sucralfate, as recommended by the American Gastroenterological Association 1
• Proton pump inhibitors (PPIs) are generally considered first-line agents for treating and preventing gastrointestinal ulcers, with sucralfate recommended as a second-line agent by the American College of Gastroenterology 2

Special Patient Populations

• In critically ill patients requiring stress ulcer prophylaxis, PPIs or H2-receptor antagonists are typically preferred over sucralfate, according to the Society of Critical Care Medicine 3
• For NSAID-induced ulcers, discontinuation of NSAIDs is recommended when possible, as suggested by the American Gastroenterological Association 1