Vaping and Deep Vein Thrombosis Risk

Risk Factors

Age over 60 years increases the risk of deep vein thrombosis (OR 1.34) 1
Immobility, defined as confinement to bed for >72 hours or being bedridden, increases the risk of deep vein thrombosis (OR 3.17) 1
History of heart failure increases the risk of deep vein thrombosis (OR 2.68) 1
History of previous venous thromboembolism increases the risk of deep vein thrombosis (OR 6.08) 1
Active malignancy increases the risk of deep vein thrombosis (OR 2.65) 1
Critical illness requiring ICU or CCU stay increases the risk of deep vein thrombosis (OR 1.65) 1
Infections, including cellulitis, pneumonia, and sepsis, increase the risk of deep vein thrombosis (OR 1.48) 1
Elevated C-reactive protein >10 mg/L increases the risk of deep vein thrombosis (OR 10.10) 1

Patients who vape and develop unexplained leg pain, swelling, or redness should be evaluated for possible deep vein thrombosis 2, 3
Healthcare providers should consider vaping as a potential risk factor when assessing a patient's overall risk for venous thromboembolism 1

Those with multiple risk factors for deep vein thrombosis should be strongly advised to discontinue vaping 1
For long-distance travelers who vape, additional preventive measures may be warranted, such as frequent movement, proper hydration, and consideration of compression stockings 2, 4