Trazodone Discontinuation Guidance

Special Considerations for Discontinuation

• Older adults may be more sensitive to discontinuation effects and require even more gradual dose reductions, according to the American Academy of Sleep Medicine 1
• Patients taking therapeutic antidepressant doses are at higher risk for withdrawal than those using low doses for sleep, and should taper gradually, as recommended by the American Academy of Sleep Medicine 1
• Even patients using trazodone at low doses for insomnia should taper gradually, though the withdrawal risk may be lower than with antidepressant doses, as suggested by the American Academy of Sleep Medicine 1