Lansoprazole Dosing and Administration in Pediatric Patients

Administration Guidelines

• Lansoprazole should be administered 30 minutes before meals for optimal acid suppression, as recommended by the American Academy of Pediatrics 1
• For children unable to swallow capsules, the delayed-release capsule can be opened and pellets mixed with applesauce, according to the American Academy of Pediatrics 2

Comparative Context with Other PPIs

• Omeprazole is dosed at 10 mg once daily for children 10-<20 kg and 20 mg once daily for children ≥20 kg, as suggested by the American Academy of Pediatrics 2
• Lansoprazole 30 mg once daily is equivalent to omeprazole 20 mg once daily, based on evidence from the Journal of Hepatology 3
• Both PPIs demonstrate superior efficacy compared to H2-receptor antagonists for pediatric GERD, as stated by the American Academy of Pediatrics 2, 1

Safety Considerations

• Long-term use (>2.5 years) of lansoprazole may be associated with enterochromaffin cell hyperplasia in up to 50% of children, according to the American Academy of Pediatrics 2