Management of Vulvovaginal Candidiasis in Patients Taking SGLT2 Inhibitors

Prevention and Risk Factors

For women with recurrent vulvovaginal candidiasis while on Jardiance, the Centers for Disease Control and Prevention recommends fluconazole 150 mg orally once weekly for 6 months as maintenance therapy, with alternative regimens including ketoconazole, itraconazole, or daily therapy with topical azoles 1
The American College of Obstetricians and Gynecologists advises that vaginal yeast infections may occur in female patients taking Jardiance, and provides information on signs and symptoms, treatment options, and when to seek medical advice, including symptoms such as vaginal itching and irritation, white discharge, and vulvar burning 2, 3

The Centers for Disease Control and Prevention recommends topical azoles for 1-7 days or fluconazole 150 mg as a single oral dose for treatment of vulvovaginal candidiasis 3
The Centers for Disease Control and Prevention advises against self-diagnosis of yeast vaginitis, as it is unreliable and can lead to inappropriate treatment, and against treating Candida in the absence of symptoms, as 10-20% of women normally harbor Candida in the vagina 1, 2, 3
The Centers for Disease Control and Prevention recommends multi-day regimens for severe or recurrent cases, as single-dose treatments are often insufficient 3

Vulvovaginal candidiasis is characterized by symptoms such as vaginal itching and irritation, white, cottage cheese-like discharge, vaginal soreness, vulvar burning, dyspareunia, and external dysuria 2, 3