Exercise-Induced Changes in Bilirubin Levels

Mechanisms and Effects

The liver's conjugation capacity can be temporarily exceeded due to increased bilirubin production caused by exercise-induced hemolysis, leading to elevated levels of indirect bilirubin 1
Dehydration during intense exercise can concentrate blood components, including bilirubin, which may affect its levels 2
It is essential to differentiate between transient elevations of bilirubin related to exercise and pathological elevations that may indicate liver or hemolytic disease 3

If exercise is suspected to be the cause of hyperbilirubinemia, it may be useful to repeat the test after 24-48 hours of rest 3