Treatment of Neurobrucellosis

Alternative Treatment Options

If ceftriaxone cannot be used, a combination of doxycycline and rifampicin with an aminoglycoside (preferably gentamicin over streptomycin) may be considered, according to Praxis Medical Insights 1

MRI should be performed when spinal involvement is suspected in neurobrucellosis, as recommended by Praxis Medical Insights 2
Aminoglycoside-containing regimens may be superior to rifampicin-containing ones for brucellar spondylitis, which may accompany neurobrucellosis, according to Praxis Medical Insights 3
Immobilization of the spine is crucial if there is cervical involvement to prevent devastating neurological complications, as reported in PLoS Medicine 4

In regions where brucellosis and tuberculosis coexist, consider the public health implications of using rifampicin, as this may contribute to mycobacterial resistance, according to Praxis Medical Insights 1