Management of Uterine Fibroids in Pregnancy

Contraindicated Interventions During Pregnancy

• The American College of Obstetricians and Gynecologists implies that all medical therapies used for non-pregnant fibroid management, including GnRH agonists, GnRH antagonists, selective progesterone receptor modulators, combined oral contraceptives, and levonorgestrel IUDs, are contraindicated during pregnancy, as they suppress fertility during treatment and have unknown or potentially harmful effects on pregnancy outcomes 1, 2, 3, 4
• The American Journal of Obstetrics and Gynecology recommends avoiding medical management with hormonal therapies or GnRH modulators during pregnancy, as these are contraindicated and potentially harmful 4, 2

Prognostic Factors and Management

• Iron supplementation should be considered if anemia develops from bleeding complications, as this is a manageable aspect of care, according to Praxis Medical Insights 1