Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/24/2025

Risks of DDAVP in Type 2B von Willebrand Disease

Treatment Options

  • For type 2B VWD patients requiring hemostatic coverage, human-derived medium-purity FVIII concentrates complexed to Willebrand factor, such as Humate-P, are the preferred treatment option, as indicated for patients with von Willebrand disease in whom desmopressin is known or suspected to be inadequate 1
  • The American Heart Association, as published in Circulation, recommends using VWF/FVIII concentrates rather than DDAVP as first-line therapy for patients with type 2B VWD requiring hemostatic coverage 1