Zolpidem-Associated Constipation

Comparison to Other Medication Classes

• Opioid medications cause constipation in 40-80% of patients taking chronic opioid therapy 1

Management of Constipation

• Ensure adequate hydration and physical activity when appropriate 2
• Dietary interventions with adequate fiber intake may be helpful for patients with sufficient fluid intake 3
• For persistent constipation, consider osmotic laxatives such as polyethylene glycol (PEG) 1
• For persistent constipation, consider stimulant laxatives such as bisacodyl or senna if needed 2

Management of Constipation

Treatment Goals and Evaluation

• The National Comprehensive Cancer Network recommends that the goal of treatment for constipation should be to achieve an unforced bowel movement every 1-2 days 4
• If constipation persists, the cause and severity should be evaluated to rule out intestinal obstruction 4