Management of Post-SSRI Sexual Dysfunction (PSSD) After SSRI Overdose

Pharmacological Treatment Options

• Alpha-1 adrenoreceptor antagonists may be considered for patients with PSSD who have failed first-line therapy, as recommended by The Journal of Urology 1
• Topical anesthetics, such as lidocaine or prilocaine, may help with certain PSSD symptoms, according to The Journal of Urology 2 and 3

Important Considerations and Precautions

• The American Academy of Child and Adolescent Psychiatry recommends avoiding serotonergic drugs to prevent serotonin syndrome, and monitoring for suicidal ideation, especially in patients under 24 years of age and those with comorbid depression 4
• The Journal of Urology suggests avoiding MAOIs, as they can interact with residual serotonergic agents and precipitate serotonin syndrome, and screening for bipolar disorder to avoid treatment with certain antidepressants that may induce mania 1 and 4