Paroxetine Pharmacokinetics and Clinical Implications

Therapeutic Drug Monitoring

• Blood samples for therapeutic drug monitoring should be collected at steady state, which for paroxetine means approximately 1 week after stable dosing, according to the Dialogues in Clinical Neuroscience 1
• Sampling should occur 12-16 hours after the last dose (or 24 hours if dosed once daily) during the terminal elimination phase, as recommended by the Dialogues in Clinical Neuroscience 1