Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/10/2025

Cost of Lisdexamfetamine (Vyvanse)

Medication Costs

  • Diabetes medications, including GLP-1 receptor agonists and SGLT2 inhibitors, show costs ranging from $223-$1,619 per 30-day supply for various agents, according to the American Diabetes Association 1, 2
  • Antiemetic medications demonstrate wide price variations between generic and brand formulations, with some generic options at $6.50 per dose versus brand options exceeding $200, as reported by the American Society of Clinical Oncology 3

Clinical Context and Dosing

  • The American College of Obstetricians and Gynecologists recommends a starting dose of 20-30 mg once daily for lisdexamfetamine, with titration by 10 mg weekly 4, 5
  • The maximum dose of lisdexamfetamine is 70 mg daily, as suggested by the American College of Obstetricians and Gynecologists 4, 5

Cost Considerations and Practical Recommendations

  • Formulation differences, such as generic versus brand-name pricing, can vary substantially, with examples like ondansetron showing 40-fold price differences, according to the American Society of Clinical Oncology 3
  • Insurance coverage, including Medicare Part D and private insurance formulary placement, significantly impacts out-of-pocket costs, as noted by the American Diabetes Association 2
  • Patients can contact the manufacturer (Takeda/Shire) directly for patient assistance programs and current wholesale pricing, as recommended by the Journal of Clinical Oncology 3
  • Checking the pharmacy benefit manager formulary can help determine tier placement and copay requirements, as suggested by the American College of Clinical Pharmacy 6