Ceftriaxone Treatment for Typhoid Fever

Dosing Guidelines

The British Journal of Pharmacology recommends ceftriaxone at a dose of 80 mg/kg/day intravenously for 5-7 days in adults and children 1
For children, an alternative approach is 50-75 mg/kg/day IV given every 12-24 hours, as suggested by Clinical Infectious Diseases 2
The British Journal of Pharmacology also recommends ciprofloxacin as a second-line option at 15 mg/kg orally twice daily for 7-10 days 1
Azithromycin is another second-line option, recommended by the British Journal of Pharmacology at 20 mg/kg orally daily for 5-7 days 1

Ceftriaxone should not be used in hyperbilirubinemic neonates, according to Clinical Infectious Diseases 2
For severe infections or complications, higher doses or longer duration may be required, as stated by Circulation 3
Failure to monitor for potential adverse effects such as biliary sludging with prolonged high-dose therapy is a common pitfall, highlighted by Clinical Infectious Diseases 2