Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/29/2025

Direct Intramyometrial Injection for Postpartum Hemorrhage Management

Efficacy and Safety

  • For ectopic pregnancy treatment, direct injection of 1 mg/kg methotrexate into the ectopic sac has been shown to be as effective as intramuscular injections with fewer side effects, suggesting that direct tissue injection of medications can be advantageous 1