Levothyroxine Administration and Monitoring

Medication Interactions

The American Academy of Family Physicians recommends taking levothyroxine at least 4 hours before or after medications that can interfere with its absorption, including iron supplements and calcium supplements 1

For pregnant women, levothyroxine requirements often increase during pregnancy, according to the American Academy of Family Physicians 1
Pregnant women should have TSH levels monitored every 6-8 weeks during pregnancy with dose adjustments as needed, as recommended by the American Medical Association 2, 3
For patients with subclinical hypothyroidism who are pregnant or planning pregnancy, levothyroxine therapy is recommended to restore TSH to normal range, as suggested by the American Medical Association 2, 3, 4