Lambert-Eaton Myasthenic Syndrome Diagnosis and Treatment

Differential Diagnosis

• The American Academy of Neurology recommends distinguishing LEMS from other causes of muscle weakness and autonomic dysfunction, including myasthenia gravis, myopathies, motor neuron disease, and other neuromuscular disorders 1, 2
• LEMS should be differentiated from other conditions with overlapping symptoms, with a thorough diagnostic approach to confirm the presence of LEMS 1, 2

Key Considerations

• Patients with LEMS may have altered sensitivity to certain medications, particularly neuromuscular blocking agents used in anesthesia, according to the European Society of Anaesthesiology 3