Transitioning from Long-Acting Injectable Paliperidone to Oral Formulations

Clinical Guidelines and Recommendations

• The British Journal of Psychiatry guidelines recommend that when transitioning from LAI to oral medication, maintaining the same active compound is preferred to minimize risk of relapse 1
• The British Journal of Psychiatry guidelines advise against abruptly discontinuing LAI paliperidone without establishing therapeutic levels of the oral medication first 1

Monitoring and Management

• Monitor closely for signs of psychotic relapse during and after the transition, being prepared to reinstate antipsychotic treatment immediately if symptoms emerge 2