Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 12/18/2025

Schedule II Controlled Substance Prescribing Across State Lines

Federal Requirements

  • The Ryan Haight Online Pharmacy Consumer Protection Act of 2008 requires prescribers to conduct at least one in-person evaluation before prescribing a controlled substance during telemedicine practice, according to the American Academy of Child and Adolescent Psychiatry 1
  • The DEA has indicated it does not intend to interfere with legitimate controlled substance prescribing during telemedicine practice, as stated by the American Academy of Child and Adolescent Psychiatry 1
  • Full medical licensure is required in the state where the patient is physically located during the telemedicine encounter, not where the patient resides, as per the American Academy of Child and Adolescent Psychiatry 1

State-Level Variations

  • Several states allow limited licensure specifically for providing telemedicine services, though these have different restrictions on scope and practice, according to the American Academy of Child and Adolescent Psychiatry 1
  • Some states mandate specific conditions for clinical encounters or require the telepsychiatrist to maintain a physical practice location in that state, as stated by the American Academy of Child and Adolescent Psychiatry 1

Prescription Drug Monitoring Programs (PDMPs)

  • Forty-one states have operational PDMPs that track Schedule II through IV (or II through V) controlled substances, as reported in the Annals of Emergency Medicine 2
  • The CDC recommends checking the state PDMP before prescribing any Schedule II medication to identify potential diversion or doctor shopping, according to Praxis Medical Insights 3

Critical Caveats for Out-of-State Prescribing

  • Prospective prescribers must assess legislation in both the state where they are licensed and where the patient is physically located, as stated by the American Academy of Child and Adolescent Psychiatry 1

Practical Recommendations

  • Verify full licensure in the state where the patient is physically located during the telemedicine encounter before prescribing any Schedule II controlled substance, as recommended by the American Academy of Child and Adolescent Psychiatry 1
  • Review both federal Ryan Haight Act requirements and specific state legislation regarding telemedicine prescribing of controlled substances, according to the American Academy of Child and Adolescent Psychiatry 1
  • Access the state PDMP in the patient's location before prescribing to identify potential diversion or concurrent prescriptions, as recommended by the Annals of Emergency Medicine and Praxis Medical Insights 2, 3

REFERENCES

1

clinical update: telepsychiatry with children and adolescents. [LINK]

Journal of the American Academy of Child and Adolescent Psychiatry, 2017

3

Controlled Substances Scheduling and Regulation [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026