FLASH Radiation Therapy with Linear Accelerators

Clinical Feasibility and Applications

• The American Society for Radiation Oncology recommends considering FLASH-RT for its potential to reduce toxicity while maintaining tumor control, as shown in preclinical models with reduced toxicity compared to conventional dose-rate RT 3
• The Novalis TX LINAC has been demonstrated to achieve intensity-modulated radiation therapy in animal models, suggesting potential for FLASH applications, with average dose rates exceeding 160-200 Gy/s at isocenter distance 1, 2