Amiodarone and Azithromycin Interaction

Mechanism and Risk Factors

• Amiodarone prolongs the action potential duration and refractory period of cardiac fibers as a class III antiarrhythmic agent, which can contribute to QT prolongation 1
• Elderly patients with multiple comorbidities are at high risk for adverse interactions between amiodarone and azithromycin 1

Pharmacokinetics and Pharmacodynamics

• Amiodarone has an extremely long half-life, with an average of 58 days, which means interactions can occur or persist for months after discontinuation 2