Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/13/2025

Initial Approach to Eye Pain

Diagnostic Evaluation

  • The American Academy of Ophthalmology recommends assessing the duration, character, and severity of pain (burning, stinging, aching) in patients with eye pain 1
  • Determine if symptoms are unilateral or bilateral in patients with eye pain 3
  • Evaluate for associated symptoms such as photophobia, wind hyperalgesia, or sensitivity to light in patients with eye pain 1, 2
  • Document recent history of ocular surgeries, infections, trauma, or chronic ocular surface abnormalities in patients with eye pain 1
  • Inquire about systemic conditions that may contribute to eye pain (migraine, fibromyalgia) in patients with eye pain 1, 2

Diagnostic Tests

  • Fluorescein staining can be used to evaluate corneal epithelial integrity and tear break-up time in patients with eye pain 6
  • Anesthetic challenge test can be used for suspected neuropathic ocular pain in patients with eye pain 1, 2

Management Approach

  • The American Academy of Ophthalmology recommends managing dry eye syndrome with ocular lubricants and treatment of underlying inflammation in patients with eye pain 1, 2
  • Neuropathic ocular pain can be considered for topical nerve regenerative therapies for peripheral pain or oral neuromodulators for central pain in patients with eye pain 1, 2

Common Pitfalls and Caveats

  • Neuropathic ocular pain is often misdiagnosed as symptoms may outweigh clinical signs in patients with eye pain 1, 2
  • Avoid using fluorescein-anesthetic combination drops for tear break-up time assessment as the anesthetic may affect test results in patients with eye pain 6