Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/27/2025

Skin Side Effects of Propranolol

Common Skin Side Effects

  • Cold extremities are a frequent side effect due to peripheral vasoconstriction caused by beta-blockade, as reported by the American Academy of Pediatrics 1, 2

Special Considerations in Pediatric Patients

  • In infants treated for infantile hemangiomas, skin side effects are less commonly reported than other adverse effects, according to the American Academy of Pediatrics 3, 4
  • When treating infantile hemangiomas, clinicians should monitor for potential skin reactions along with more common side effects, as recommended by the American Academy of Pediatrics 4, 5

Management of Skin Side Effects

  • For mild reactions, dose reduction may be sufficient, as suggested by the American Academy of Pediatrics 2
  • For infantile hemangioma treatment, alternative options include topical timolol or systemic corticosteroids, as recommended by the American Academy of Pediatrics 3, 6

Monitoring Recommendations

  • Patient education about potential skin side effects and when to seek medical attention is crucial, as emphasized by the American Academy of Pediatrics 4, 5