Bleeding Risk Associated with Apixaban and NSAID Use

Introduction to Bleeding Risk

• The American Academy of Otolaryngology-Head and Neck Surgery identifies anticoagulants and antiplatelet medications, including NSAIDs, as causing increased bleeding episodes, larger blood loss volumes, and higher transfusion requirements 1

Patient Management

• The American College of Cardiology recommends avoiding NSAID use in high-risk scenarios, including elderly patients (>75 years) and those with renal impairment (CrCl <50 mL/min) 2