Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Monitoring Frequency for the 9-Hole Peg Test in MS Patients

Standard Testing Frequency Guidelines

  • The National Multiple Sclerosis Society recommends that the 9-hole peg test should be performed every 6 months in most MS patients to effectively monitor upper limb function changes while minimizing practice effects 1
  • The European Committee for Treatment and Research in Multiple Sclerosis recommends that this testing frequency parallels recommendations for other MS monitoring tools, such as brain MRI scans which are recommended at similar intervals 2, 3

Adjusted Testing Frequency Based on Risk Factors

  • The American Academy of Neurology recommends more frequent monitoring (every 3-4 months) in high-risk patients, particularly those on disease-modifying therapies with increased risk of complications 2, 3
  • The Multiple Sclerosis International Federation recommends that patients with JCV seropositive status and treatment duration ≥18 months require more frequent monitoring (every 3-4 months) 3
  • The National Institute of Neurological Disorders and Stroke recommends that patients showing signs of rapid disease progression require more frequent monitoring (every 3-4 months) 1
  • The European Multiple Sclerosis Platform recommends that annual testing may be sufficient for patients with stable disease and minimal symptoms 3

Clinical Considerations for Testing

  • The American College of Rehabilitation Medicine recommends that the 9-hole peg test should be integrated with other MS monitoring approaches, including regular brain MRI scans and clinical assessments 1

Special Monitoring Considerations

  • The Consortium of Multiple Sclerosis Centers recommends that patients switching between disease-modifying therapies should undergo more frequent monitoring (every 3-4 months) for up to 12 months after the switch 2