Oral Medications for Methamphetamine Abuse

Current State of Pharmacotherapy

• Currently, there are no FDA-approved oral medications for the treatment of methamphetamine use disorder, and behavioral therapies remain the primary evidence-based treatment approach, according to the American Academy of Family Physicians 1
• Behavioral therapies remain the mainstay of treatment for methamphetamine dependence, as they have demonstrated effectiveness where medications have not, as recommended by the American Academy of Family Physicians [1, @42@]

Acute Intoxication Management

• When managing acute methamphetamine intoxication or overdose, benzodiazepines are first-line therapy for agitation, hypertension, and tachycardia—but this addresses acute toxicity, not chronic use disorder 2