Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/30/2025

Duration of Intravenous Catheter Placement

Peripheral Intravenous Catheters

  • The Infectious Diseases Society of America recommends removing peripheral IV catheters based on clinical indication only, rather than at fixed time intervals, as routine replacement every 72-96 hours provides no infection benefit and increases costs and patient discomfort 1
  • There is no need to replace peripheral catheters more frequently than every 72-96 hours to reduce infection or phlebitis risk in adults, though this represents a maximum rather than mandatory replacement interval 1
  • In children, replace peripheral catheters only when clinically indicated 1
  • Remove peripheral IV catheters when signs of phlebitis develop, such as pain, tenderness, erythema, warmth, or palpable cord 1
  • Remove peripheral IV catheters when the catheter becomes occluded or malfunctions 2
  • Remove peripheral IV catheters when a patient develops fever without an obvious source 1

Midline Catheters

  • Replace midline catheters only when there is a specific clinical indication 1
  • Midline catheters are appropriate for 6-14 days of peripherally compatible infusates in general medical patients 3, 4

Central Venous Catheters (CVCs) and PICCs

  • The Infectious Diseases Society of America recommends not routinely replacing CVCs, PICCs, or pulmonary artery catheters to prevent catheter-related infections 1
  • Do not remove CVCs or PICCs based on fever alone; use clinical judgment regarding infection evidence elsewhere 1
  • Internal jugular non-cuffed catheters should not be used for more than 1 week due to exponentially increasing infection risk 2
  • Femoral catheters should not remain in place longer than 5 days and should only be used in bed-bound patients with good exit-site care 2
  • Tunneled, cuffed catheters are preferred for longer durations of hemodialysis therapy over non-cuffed catheters due to significantly lower infection rates 2
  • Tunneled, cuffed catheters can provide access over a period of months 2
  • Non-cuffed catheter infection rates are more than 5 times greater with internal jugular catheters and almost 7 times greater with femoral catheters compared to tunneled cuffed catheters 2

Administration Sets and Tubing

  • Replace administration sets no more frequently than at 96-hour intervals, but at least every 7 days for patients not receiving blood, blood products, or fat emulsions 5, 6, 7, 8
  • Replace tubing for blood, blood products, or fat emulsions within 24 hours of initiating infusion 5, 6, 7, 8
  • Replace propofol infusion tubing every 6 or 12 hours when the vial is changed per manufacturer recommendations 5, 6, 7, 8
  • Change needleless components at least as frequently as the administration set, with no benefit to changing more frequently than every 72 hours 5, 6, 7, 8
  • Scrub access ports with appropriate antiseptic before each access 5, 6, 7, 8

Umbilical Catheters (Neonatal)

  • Umbilical artery catheters should optimally not remain in place more than 5 days 2, 9
  • Umbilical venous catheters can be used up to 14 days if managed aseptically 2, 9
  • Remove umbilical catheters immediately if signs of catheter-related bloodstream infection, vascular insufficiency, or thrombosis develop 9

Common Pitfalls to Avoid

  • Do not routinely replace peripheral IVs at fixed intervals (72-96 hours) as this increases costs, patient discomfort, and catheter insertions without reducing complications 1
  • Do not discharge patients with non-cuffed central catheters due to risks of infection, inadvertent removal, and hemorrhage 2
  • Do not use femoral catheters for more than 5 days in non-bed-bound patients 2
  • Do not fail to monitor for signs of infection, including exit site changes, fever, or systemic symptoms 2