Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 12/2/2025

Management of Perioperative Pain

Principles of Pain Assessment

  • The American Society of Anesthesiologists recommends that patient self-assessment is the most valuable tool for measuring pain, using validated scales such as NRS, VAS, or VRS 4
  • For non-communicative patients, observational scales like BPS or CPOT should be applied, although they are less reliable than patient-reported metrics 5, 4
  • The American College of Surgeons suggests that functional assessment should guide the provision of opioid analgesia, not solely unidimensional pain scores 2, 6
  • A CPOT score >2 has a sensitivity of 86% and specificity of 78% for predicting significant pain in postoperative adults 5

Multimodal Analgesia Strategy

  • The World Health Organization recommends administering acetaminophen at the start of postoperative analgesia, as it is safer and more effective than other drugs 1, 3
  • Preemptive therapy with acetaminophen (1g before laparotomy) reduces opioid side effects, hospital stay, and costs 1, 3
  • The American Academy of Pain Medicine suggests that AINEs are more effective than opioids for surgical dental pain and kidney stones 7
  • Coxibs should be considered if there are no contraindications 1
  • Preemptive and preventive administration of AINEs reduces pain and morphine use 3

Interventional Strategies

  • The American Society of Regional Anesthesia and Pain Medicine recommends epidural anesthesia/analgesia for postoperative analgesia in patients undergoing abdominal aortic surgery 5
  • The combination of multimodal systemic analgesia with regional analgesia is recommended 4
  • Infiltration of the surgical site with local anesthetic is a key component of multimodal analgesia 8, 9

Monitoring and Reevaluation

  • The American Pain Society recommends that periodic evaluation of pain scores is mandatory using validated systems to assess response to treatments and allow adjustments 10, 4
  • Monitoring 24 hours/day with regular evaluation and documentation ensures better pain treatment 3
  • After a pain intervention, the patient should be reevaluated for both pain control and adverse reactions at an appropriate interval 3

Special Considerations

  • The American Society of Anesthesiologists suggests that patients with chronic opioid use should be considered for opioid tapering before surgery if feasible 2
  • The dose of opioids should be adjusted by age (not weight) and consider renal function 2
  • Patients tolerant to opioids may require additional interventions in the post-anesthesia care unit to facilitate optimal pain management 2

Transition and Discharge

  • The Centers for Disease Control and Prevention recommends using a patient-centered approach to limit the number of pills and duration of opioid prescriptions at discharge, typically to less than one week 6
  • Automatic post-discharge opioid prescription refills should be avoided; patient review should be performed if more opioids are requested 6
  • The oral route should be used as soon as possible for medication administration 2