Melanoma Screening and Prevention for BRCA2 Carriers

Introduction to Melanoma Risk

• The National Comprehensive Cancer Network recommends that BRCA2 carriers conduct monthly skin self-examinations and receive annual skin and eye examinations by a healthcare provider to screen for melanoma 1, 2
• Studies have shown inconsistent results regarding the association between BRCA2 mutations and melanoma, though there is some evidence of an increased risk 3, 4

Key Symptoms to Monitor

• The American College of Dermatology suggests using the ABCDEs of melanoma to identify suspicious lesions: Asymmetry, Border irregularity, Color variation, Diameter larger than 6mm, and Evolving changes 5
• The National Comprehensive Cancer Network recommends paying special attention to feet, shoulders, legs, and genital areas during self-examinations, as well as thorough examination of the eyes due to increased risk of ocular melanoma 4, 1

Recommended Screening Protocol

• The National Comprehensive Cancer Network suggests performing monthly thorough skin self-examinations and documenting any suspicious lesions with photographs to track changes over time 5, 6
• Annual full-body skin examination by a dermatologist or primary care provider, as well as annual eye examination to screen for ocular melanoma, are recommended 1, 2
• More frequent examinations may be necessary if there is a personal or family history of melanoma 5, 6

Risk Reduction Strategies

• The National Comprehensive Cancer Network recommends minimizing ultraviolet exposure by avoiding tanning beds and limiting sun exposure during peak hours (10 AM to 4 PM) 7

Common Pitfalls to Avoid

• The American Academy of Dermatology warns against assuming that melanomas always follow the typical ABCDE pattern, as some may be amelanotic (lacking pigment) 5