Valsartan/HCTZ Dosing Guidelines

Heart Failure Dosing

• The American Heart Association recommends valsartan 160 mg twice daily (total 320 mg/day) without HCTZ for heart failure with reduced ejection fraction, with a strength of evidence based on guidelines from Circulation and the Journal of the American College of Cardiology 1, 2

Monitoring and Contraindications

• The American College of Cardiology and other guideline societies advise checking serum potassium and creatinine within 1-2 weeks after initiating or increasing valsartan/HCTZ doses, particularly in patients with baseline renal impairment, and avoiding combination with ACE inhibitors due to increased risk of hyperkalemia and renal dysfunction, based on evidence with a moderate strength of recommendation 3