Tamoxifen Treatment for Male Gynecomastia

Dosing and Administration

• The maximum recommended dose of tamoxifen for treating gynecomastia in men is 20 mg daily for up to 3-6 months, as recommended by the American College of Clinical Oncology 1
• Standard dosing for gynecomastia treatment is 20 mg per day orally, according to the American College of Clinical Oncology 1

Important Considerations

• Tamoxifen is not FDA-approved specifically for gynecomastia treatment, but is used off-label, as noted by the American College of Clinical Oncology 1
• Patients should be monitored for potential side effects including thromboembolic events, though these are rare in men taking tamoxifen for gynecomastia, as recommended by the American College of Clinical Oncology 1

Contraindications

• A history of deep vein thrombosis, pulmonary embolism, stroke, or transient ischemic attack is a contraindication for tamoxifen use, as stated by the American College of Clinical Oncology 1
• Prolonged immobilization is a contraindication for tamoxifen use, according to the American College of Clinical Oncology 1
• Concurrent use with hormone therapy is a contraindication for tamoxifen use, as noted by the American College of Clinical Oncology 1