Host Factors Predisposing to Klebsiella Septicemia

Primary Host Risk Factors

Neutropenia and poorly controlled HIV infection significantly increase susceptibility to Klebsiella infections in patients, according to the Society of Critical Care Medicine 1
Acquired or congenital defects of immunoglobulin, complement, or leukocyte function predispose to severe Klebsiella infections, as noted by the Society of Critical Care Medicine 1
Splenectomy removes critical immune defenses against encapsulated organisms like Klebsiella, as reported by the Society of Critical Care Medicine 1

Prolonged hospitalization is a major risk factor for multidrug-resistant Klebsiella, as stated by the Centers for Disease Control and Prevention 3 and the Centers for Disease Control and Prevention 4
Critically ill patients with severe sepsis or septic shock have a higher probability of resistant isolates, according to the Society of Critical Care Medicine 1

Oncological diseases increase susceptibility to both infection and sepsis, as reported by the Infectious Diseases Society of America 5
Hematopoietic stem cell transplantation creates significant vulnerability to Klebsiella infections, as noted by the Infectious Diseases Society of America 5
Proton pump inhibitor use is associated with increased infection risk, though evidence for discontinuation as primary prevention is limited, as stated by the Infectious Diseases Society of America 5

Advanced age (>65 years) is a general risk factor for sepsis development, as reported by the American College of Radiology 2