Treatment of Major Depressive Disorder with Mixed Features

Standard Treatment Options

• The American College of Physicians guidelines recommend second-generation antidepressants (SSRIs, SNRIs) with or without psychotherapy as first-line treatment for major depressive disorder (MDD) 1, 2
• Cognitive behavioral therapy (CBT) shows equivalent efficacy to antidepressants in treating MDD 4, 3

Atypical Antipsychotics in MDD Treatment

• Atypical antipsychotics like lurasidone are only FDA-approved as adjunctive treatment in treatment-resistant unipolar MDD, not as monotherapy 1, 2