Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/17/2025

Treatment for Umbilical Smell with Drainage

Assessment and Diagnosis

  • Umbilical discharge with odor often indicates infection, which may be bacterial colonization of the umbilical stump or surrounding tissues, with common pathogens including Staphylococcus aureus, group A and B Streptococci, and Gram-negative bacilli such as Escherichia coli, Klebsiella species, and Pseudomonas species, according to the American Academy of Pediatrics 1
  • Assess for signs of more serious infection such as periumbilical erythema, tenderness, purulent discharge, or systemic signs of infection, as recommended by the American Academy of Pediatrics 1

Treatment Approach

Immediate Management

  • Cleanse the umbilical area with an antiseptic solution such as povidone-iodine, avoiding tincture of iodine in neonates due to potential thyroid effects, as suggested by the Infectious Diseases Society of America 2, 1
  • Do not apply topical antibiotic ointments or creams to the umbilical area, as they may promote fungal infections and antimicrobial resistance, according to the Infectious Diseases Society of America 2, 3

For Moderate to Severe Infections

  • For cases with significant inflammation, spreading cellulitis, or systemic symptoms, systemic antibiotics are indicated, with initial empiric therapy covering Staphylococcus aureus and Streptococcus species, as recommended by the American Academy of Pediatrics 1

Special Considerations

For Neonates

  • The World Health Organization recommends dry cord care for hospital births or in settings with low neonatal mortality, and application of 4% chlorhexidine solution or gel to the umbilical cord stump within 24 hours after birth for home births or in settings with high neonatal mortality, according to the World Health Organization 1
  • Remove umbilical catheters immediately if any signs of catheter-related bloodstream infection are present, as recommended by the Infectious Diseases Society of America and other guidelines 2, 4

Prevention

  • Ensure the umbilical area is thoroughly dried after bathing, as recommended by the American Academy of Pediatrics 1