Mounjaro Administration and Safety Considerations

Critical Safety Considerations

• The American College of Surgeons recommends discontinuing Mounjaro at least 3 days before planned surgery to prevent postoperative ketoacidosis, similar to other incretin-based therapies 1
• The American Society of Anesthesiologists suggests monitoring for signs of delayed gastric emptying, particularly in the perioperative setting 2

Use with Other Diabetes Medications

• The Mayo Clinic recommends continuing metformin unless contraindicated when starting Mounjaro 3
• The American Diabetes Association suggests considering reducing or stopping sulfonylureas to minimize hypoglycemia risk 4

Renal Considerations

• The National Kidney Foundation states that no dosage adjustments are required for patients with kidney disease, and Mounjaro can be used in patients with eGFR ≥45 mL/min/1.73 m² without dose modification 5, 3