AUA Guideline Insights on Alpha‑Blocker Safety in Benign Prostatic Hyperplasia

Orthostatic Hypotension

• The American Urological Association (AUA) guidelines indicate that tamsulosin is associated with a lower probability of orthostatic hypotension compared with non‑selective α‑blockers such as doxazosin and terazosin; silodosin was not evaluated because it was not yet available at the time of the guideline publication. 1

Ejaculatory Dysfunction

• According to the AUA guidelines, tamsulosin carries a higher probability of ejaculatory dysfunction than older non‑selective α‑blockers used for BPH treatment. 1