Contraindications and Precautions for Clavulanate Use

Gastrointestinal Sensitivity and Alternative Therapies

• The clavulanate component limits the maximum daily dose due to its gastrointestinal adverse effects, according to Praxis Medical Insights 1
• For adults with penicillin allergy, the American Academy of Otolaryngology-Head and Neck Surgery recommends alternative options such as doxycycline or respiratory fluoroquinolones (levofloxacin or moxifloxacin) 2
• For children with non-type I penicillin allergy, Praxis Medical Insights suggests alternative options such as clindamycin plus a third-generation oral cephalosporin 3