Combination Therapy for Hypertension Management with Losartan

Available Combinations and Efficacy

• The European and American cardiology societies recommend losartan/hydrochlorothiazide (HCTZ) as an effective combination therapy for hypertension management 1, 2
• Fixed-dose combinations, such as losartan/HCTZ, improve medication adherence compared to taking separate pills, which is critical for achieving long-term blood pressure control 3
• Patients who need more than one agent to achieve blood pressure control may benefit from losartan/HCTZ combination therapy, as recommended by the European cardiology society 2

Therapeutic Considerations and Potential Pitfalls

• The combination of two RAS blockers, such as adding an ACE inhibitor to losartan, is not recommended due to increased risk of hyperkalemia and renal dysfunction, as advised by the European cardiology society 2