Complications of Polyethylene Glycol 3350

Common Side Effects

Nausea occurs frequently but is typically mild and resolves without intervention 1, 2, 3
Abdominal bloating and cramping are common, especially during initial treatment 2, 3
Diarrhea can develop, particularly with higher doses or in sensitive individuals 2
Anal irritation may occur with frequent bowel movements 1, 3

Unlike some other laxatives, PEG 3350 does not cause significant net gain or loss of sodium and potassium 3
PEG 3350 is minimally absorbed systemically, which contributes to its favorable safety profile 3
When used for bowel preparation for colonoscopy, higher volumes are required which may increase the risk of side effects 1, 4
The American Gastroenterological Association recommends adequate hydration to prevent dehydration during treatment with PEG 3350 3