Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/5/2025

Management of Nummular Eczema

Topical Corticosteroid Therapy

  • The American Academy of Dermatology recommends applying high-potency or ultra-high potency topical corticosteroids 2-3 times daily to the affected areas, as first-line treatment for nummular eczema flare-ups, combined with aggressive emollient therapy is not cited, however, liberal and frequent application of emollients is mandatory and should be continued even after lesions appear controlled 1
  • Apply emollients immediately after bathing to provide a surface lipid film that retards water loss 1

Emollient Therapy and Skin Care

  • Use soap-free cleansers and avoid hot water baths, as these remove natural skin lipids and are common aggravating factors 2

Managing Pruritus

  • Sedating antihistamines, such as diphenhydramine, should be prescribed exclusively at nighttime to help patients sleep through severe itching episodes 1, 2
  • Large doses of sedating antihistamines may be required in children to achieve adequate symptom control 3

Identifying and Treating Secondary Infection

  • Watch for increased crusting, weeping, or pustules—these indicate secondary bacterial infection requiring oral antibiotics 1, 2
  • Flucloxacillin is the first-line oral antibiotic for Staphylococcus aureus, the most common pathogen 1, 2

Preventing Relapse After Clearing

  • After achieving clearance, implement proactive (weekend) therapy with topical corticosteroids applied twice weekly to previously affected sites 4
  • Continue aggressive emollient use daily, even when skin appears clear 1

Common Pitfalls to Avoid

  • Do not delay or withhold topical corticosteroids when infection is present—they remain the primary treatment when appropriate systemic antibiotics are given 1
  • Avoid using continuous topical corticosteroids without breaks—implement "steroid holidays" when possible to minimize side effects 1, 3

When to Escalate or Refer

  • Failure to respond to high-potency topical corticosteroids after 4 weeks warrants referral 1
  • Systemic corticosteroids have a limited role only for severe cases after exhausting all other options, and should never be used for maintenance 1, 3