Oral Semaglutide and Levothyroxine Co-administration Guidelines

Introduction to Co-administration

• The American College of Cardiology suggests that patients taking oral semaglutide and levothyroxine should follow a specific administration protocol to minimize drug-drug interactions and optimize absorption of both medications, with a total fasting time of 60 minutes from oral semaglutide dose to first food intake 1

Special Patient Considerations

• The American College of Cardiology recommends careful monitoring for patients with prior gastric surgery, as GLP-1 receptor agonists like semaglutide may delay gastric emptying and slow absorption of concomitantly administered oral medications, although this effect is usually transient with longer-acting GLP-1 receptor agonists 2