Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/31/2025

Management of Neonatal Jaundice

Assessment of Bilirubin Values

  • The American Academy of Pediatrics recommends that phototherapy is typically considered when total bilirubin levels exceed 15-20 mg/dL depending on age and risk factors in infants 2
  • The direct bilirubin of 0.6 mg/dL is considered normal, as direct bilirubin is considered abnormal only when it exceeds 1.0 mg/dL if the total serum bilirubin is at or below 5 mg/dL, according to the American Academy of Pediatrics 3

Clinical Approach

  • The American Academy of Pediatrics suggests verifying that the infant is feeding well, with adequate output and appropriate weight gain, to ensure adequate bilirubin elimination 3
  • Assessing for any signs of dehydration is crucial, as maintaining adequate hydration helps with bilirubin excretion, as recommended by the American Academy of Pediatrics 2

Follow-up Recommendations

  • Routine well-child follow-up is appropriate for infants beyond the first week of life with normal bilirubin values, according to the American Academy of Pediatrics 4