PSA Response to Lu-177 PSMA Therapy

Monitoring and Interpreting PSA Response

• PSA velocity (rate of change) can provide useful information and increase the specificity of PSA testing for monitoring treatment response 1
• PSA is not a cancer-specific marker, and various factors can affect PSA levels, including infection, recent instrumentation, ejaculation, or trauma 2
• Different commercial PSA assays are not directly comparable or interchangeable since values are calibrated against different standards 2
• When interpreting PSA changes, it's essential to consider that patients may have a long survival even if hormonal treatment is delayed until evidence of metastases 3