Cinacalcet Dosage and Administration for Parathyroid Hormone Control

Special Considerations

• Cinacalcet should be used with caution in X-linked hypophosphatemia due to risk of severe hypocalcemia and increased QT interval 2
• Consider cinacalcet as adjuvant treatment in patients with X-linked hypophosphatemia and persistently elevated PTH levels despite optimization of active vitamin D and phosphate doses 1
• Benefits in CKD may be limited to preventing parathyroidectomy in patients for whom surgery is contraindicated 3
• Cinacalcet has little or no effect on all-cause mortality (RR 0.97) in end-stage CKD 4, 3
• The use of cinacalcet is associated with an increased risk of hypocalcemia (RR 7.38), nausea (RR 2.05), vomiting (RR 1.95), and diarrhea (RR 1.15) 3