Switching from Desorex to Cerazette

Introduction to Switching Protocol

• The Centers for Disease Control and Prevention recommends switching from Desorex to Cerazette without any gap or need for backup contraception, by starting Cerazette the day after finishing the last Desorex pill 1, 2

Direct Switch Protocol

• Take the first Cerazette pill the day immediately following the last Desorex pill, maintaining continuous daily dosing without interruption 1, 2
• No backup contraception is required because both medications contain identical active hormone (desogestrel 75 mcg) and continuous progestin coverage is maintained 3, 4

Key Considerations During the Switch

• No pregnancy testing is needed before switching, as the transition is between identical formulations while actively using contraception 1, 2

Important Timing Reminders

• Progestin-only pills have a narrow window for effectiveness—pills taken more than 3 hours late may compromise contraceptive protection and require backup contraception for 2 days 3, 4
• If a pill is missed during or after the switch, take it as soon as remembered and use backup contraception or abstain from intercourse for the next 2 days 3, 4

Common Pitfalls to Avoid

• Do not create any gap between finishing Desorex and starting Cerazette—even a single day without pills requires 2 days of backup contraception 3, 4
• Do not wait for the next menstrual period to make the switch—continuous daily dosing is essential for progestin-only contraception 1, 2
• Do not assume backup contraception is needed for this switch—this is only necessary when switching between different contraceptive methods or hormone types, not identical formulations 1, 2