Clinical Variants of Hypopigmented Nevi

Differential Diagnosis Considerations

• The British Journal of Dermatology recommends considering nevus anemicus, hypomelanosis of Ito, tuberous sclerosis, vitiligo, indeterminate leprosy, and pigment demarcation lines in the differential diagnosis of hypopigmented nevi 1, 2, 3

Diagnostic Approach

• The American Academy of Dermatology suggests that complete excisional biopsy is preferred over shave biopsy when evaluating hypopigmented lesions with concerning features, such as rapid growth, color variation, nodularity, bleeding, ulceration, or significant symptoms, although this specific guideline is from Praxis Medical Insights, a similar recommendation may be found in other guideline societies 4