Management of Urine Candida auris Infections

Treatment Approach

The Infectious Diseases Society of America recommends that antifungal therapy for urinary Candida auris should be continued for 14 days after documented clearance of the organism from urine cultures and resolution of symptoms attributable to the infection 3, 4
Liposomal amphotericin B (3-5 mg/kg daily) is an effective alternative for treating C. auris infections, particularly in cases where echinocandins cannot be used 1
Conventional amphotericin B deoxycholate (0.7-1.0 mg/kg/day) can be considered in settings where liposomal formulations are unavailable 2, 1

Repeat urine cultures should be performed to document clearance of the organism, and persistent positive cultures may indicate inadequate source control, resistance development, or presence of foreign bodies (catheters) 3, 4, 1
Removing urinary catheters whenever possible is recommended, as catheterization is a common risk factor for C. auris infection 2
Premature discontinuation of antifungal therapy may lead to recurrent infection, particularly in immunocompromised patients 6
Failure to remove urinary catheters when possible can lead to persistent infection despite appropriate antifungal therapy 2, 1